The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. Princeton, N.J.: Medical Examination, 1983. Schade DS, Santiago JV, Skyler JS, Rizza RA. Same as for lente insulin in addition, peak of action is erratic in some patients. Zinc suspension binds with regular insulin, which loses its effect if it is left in the syringe for more than a few minutes. In many patients, breakfast injection does not last until the evening meal administration with the evening meal does not meet insulin needs on awakening. Lag time is not used appropriately the insulin should be given 20 to 30 minutes before the patient eats. Hypoglycemia occurs if the lag time is too long or the patient exercises within one hour of administration with high-fat meals, the dose should be adjusted downward. Flexible insulin regimens are based on predetermined actions in response to self-monitoring of blood glucose levels and carbohydrate intake.Ĭost per vial for brand name insulin (generic insulin) * Newly diagnosed patients may have lower initial requirements because of continued endogenous insulin production. Patients with type 1 diabetes typically require an insulin dosage of 0.5 to 1.0 unit per kg per day. Long-acting insulin can be administered once daily at bedtime or, ideally, twice daily in addition to another type of insulin. Intermediate-acting and long-acting insulins should not be given to account for the content of a specific meal. The premeal dose of insulin lispro can be adjusted based on the content of the meal and the patient's blood glucose level. Rapid-acting insulin lispro is an ideal mealtime insulin. Patient factors, including individual variations in insulin absorption, levels of exercise and types of meals consumed, also influence the effectiveness of an insulin regimen. Factors such as onset, peak and duration of action can influence the ability of a particular insulin regimen to help control glucose levels. In particular, new insulin strategies have improved the ability to maintain near-normal glycemia. The management of type 1 diabetes mellitus (formerly known as insulin-dependent diabetes) has changed dramatically over the past 30 years.
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